Fig. 5
From: Discovery of a dual inhibitor of NQO1 and GSTP1 for treating glioblastoma
The anticancer effect of depleting NQO1 and GSTP1 in the nude mice model. a U87MG/EGFRvIII cells were stably knocked down with NQO1, GSTP1 or both. The images of stable cell lines were captured by a fluorescence microscope. Scale bar: 50 μm; b Immunoblotting validated that protein levels of GSTP1 and NQO1 in four different stable cell lines. c Tumor growth suppression by depletion of both NQO1 and GSTP1 in nude mice. d Tumor volume curve. Tumor growth suppression in nude mice by both depletion of NQO1 and GSTP1. e Tumor weight of the mice at the endpoint. f H&E, Ki67 and TUNEL staining of tumor slices in various groups. Scale bar: 100 μm. Significant differences are considered when *p < 0.05; **p < 0.01; ***p < 0.001