Fig. 1

Impact of XPO1 expression on patient survival in DLBCL. a In the entire cohort, DLBCL patients with high level of XPO1 expression (XPO1^high) had significantly worse OS and PFS than those with low or negative XPO1 expression (XPO1^low). b XPO1^high remarkably worsened the OS/PFS of DLBCL patients with BCL2^high expression. c XPO1^high significantly worsened the OS/PFS of patients with dual MYC^highBCL2^high expression, and showed a trend of unfavorable effect on OS in patients with dual MYC/BCL2 rearrangements (MYC-R⁺BCL2-R⁺, HGBCL-DH). d In TP53-mutated (Mut) DLBCL patients without Mut-p53 overexpression, XPO1^high showed a trend of unfavorable prognostic effect on OS. e In Mut-TP53 DLBCL patients with Mut-p53 overexpression, XPO1^high showed favorable prognostic effect, which was not significant in overall patients but significant in the subset with low BCL2 expression. f Significantly differentially expressed genes between XPO1^high and XPO1^low patients with concurrent Mut-TP53 and MYC^high