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Table 2 List of the current clinical trials or drugs that are targeting immunosenescence

From: Immunosenescence: a key player in cancer development

Treatment Clinical trial/drugs Target References
Third-gen CAR-T cells containing CD28 + CD137 NCT02186860 CD28 [41]
Second-gen CMV-selected CAR-T cells against HER2 containing CD28.zeta signaling domain NCT01109095 CD28 [41]
TAB08 NCT01990157 CD28 [41]
IL-7 IL-7 Thymic [19]
KGF (keratinocyte growth factor) KGF Thymic [19]
IL-22 IL-22 Thymic [19]
Ghrelin Ghrelin Thymic [19]
CDK4 inhibitors CDK4 inhibitors CDK4 [166]
Rapamycin Rapamycin MTOR [166]
Metformin Metformin Mitochondrial respiration [166]
NAD precursors NAM\NR NAD metabolism [166]
Sirtuin-activating compounds Resveratrol or trans-resveratrol\SRT2104\nicotinamide riboside Sirtuin [212]