Treatment | Clinical trial/drugs | Target | References |
---|---|---|---|
Third-gen CAR-T cells containing CD28 + CD137 | NCT02186860 | CD28 | [41] |
Second-gen CMV-selected CAR-T cells against HER2 containing CD28.zeta signaling domain | NCT01109095 | CD28 | [41] |
TAB08 | NCT01990157 | CD28 | [41] |
IL-7 | IL-7 | Thymic | [19] |
KGF (keratinocyte growth factor) | KGF | Thymic | [19] |
IL-22 | IL-22 | Thymic | [19] |
Ghrelin | Ghrelin | Thymic | [19] |
CDK4 inhibitors | CDK4 inhibitors | CDK4 | [166] |
Rapamycin | Rapamycin | MTOR | [166] |
Metformin | Metformin | Mitochondrial respiration | [166] |
NAD precursors | NAM\NR | NAD metabolism | [166] |
Sirtuin-activating compounds | Resveratrol or trans-resveratrol\SRT2104\nicotinamide riboside | Sirtuin | [212] |