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Table 2 List of the current clinical trials or drugs that are targeting immunosenescence

From: Immunosenescence: a key player in cancer development

Treatment

Clinical trial/drugs

Target

References

Third-gen CAR-T cells containing CD28 + CD137

NCT02186860

CD28

[41]

Second-gen CMV-selected CAR-T cells against HER2 containing CD28.zeta signaling domain

NCT01109095

CD28

[41]

TAB08

NCT01990157

CD28

[41]

IL-7

IL-7

Thymic

[19]

KGF (keratinocyte growth factor)

KGF

Thymic

[19]

IL-22

IL-22

Thymic

[19]

Ghrelin

Ghrelin

Thymic

[19]

CDK4 inhibitors

CDK4 inhibitors

CDK4

[166]

Rapamycin

Rapamycin

MTOR

[166]

Metformin

Metformin

Mitochondrial respiration

[166]

NAD precursors

NAM\NR

NAD metabolism

[166]

Sirtuin-activating compounds

Resveratrol or trans-resveratrol\SRT2104\nicotinamide riboside

Sirtuin

[212]