Table 3 Small-molecule compounds targeting Wnt/β-catenin cascade to inhibit cancer stem cells
From: Targeting the Wnt/β-catenin signaling pathway in cancer
Agents | Target | Phase | Type of cancer | Side effects | References |
|---|---|---|---|---|---|
WNT974 | PORCN inhibitor | Phase I | Breast cancer | Not reported | Solzak JP et al. [136] |
Niclosamide | Wnt/β-catenin | Phase II | Colorectal cancer | Vomiting, diarrhea, and colitis | Burock S et al. [140] |
Wnt/β-catenin | Preclinical | Ovarian cancer | Not reported | Lin CK et al. [137] | |
LRP6, β-catenin | Preclinical | Basal-like breast cancer | Not reported | Ye T et al. [139] | |
ONC201 | Wnt/β-catenin | Phase I/ II | Glioblastoma cancer | Not reported | Arrillaga-Romany I et al. [144] |
Preclinical | Prostate cancer | Not reported | Lev A et al. [143] | ||
XAV939 | Tankyrase inhibitor | Preclinical | Colon cancer | Not reported | Wu X et al. [147] |
Preclinical | Head and neck squamous cell carcinoma | Not reported | Roy S et al. [146] | ||
IWR-1 | Tankyrase inhibitor | Preclinical | Osteosarcoma | Not reported | Martins-Neves SR et al. [148] |
TFP | Wnt/β-catenin | Preclinical | Lung cancer | Not reported | Yeh CT et al. [118] |
AD and Ts | Wnt/β-catenin | Preclinical | Lung cancer | Not reported | Lamture G et al. [165] |
Chelerythrine | β-catenin | Preclinical | Non-small cell lung carcinoma | Not reported | Medvetz D et al. [150] |
Wnt-C59 | PORCN inhibitor | Preclinical | Nasopharyngeal carcinoma | Not reported | Cheng Y et al. [152] |
IC-2 | Wnt | Preclinical | Hepatocellular carcinoma | Not reported | Seto K et al |
Preclinical | Colorectal cancer | Not reported | Urushibara S et al | ||
JIB-04 | β-catenin | Preclinical | Colorectal cancer | Not reported | Kim M et al. [153] |
FH535 | Wnt/β-catenin | Preclinical | Pancreatic cancer | Not reported | Razak S et al. [155] |
Docetaxel and sulforaphane | β-catenin | Preclinical | Breast cancer | Not reported | de Bessa Garcia SA et al. [157] |
Pyrvinium pamoate | β-catenin | Preclinical | Breast cancer | Not reported | Xu L et al. [158] |
SKL2001 | Axin/β-catenin | Preclinical | Mesenchymal stem cell | Not reported | Jiwon Choi et al. [159] |