Fig. 3From: Molecular and cellular mechanisms of aging in hematopoietic stem cells and their nichesModels for aging-driven expansion of Plt/My-bi HSCs. Two models were proposed to explain the origin of Plt/My-bi HSCs. a. The Plt/My-bi HSCs are generated during the Bala-HSC proliferation. b Plt/My-bi HSCs are expanded from pre-existing Plt/My-bi HSCs in young adultsBack to article page