Fig. 4
From: Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches
Models for aging-related changes in symmetric and asymmetric division in HSCs. a Asymmetric division of HSCs helps to maintain functional HSC numbers by distributing stemness factors to one of the daughter cells and differentiation factors to the other. b Symmetric division of HSCs leads to a gradual dilution of their stemness during each division until it is practically absent. c More HSCs in young mice undergo asymmetric division; they switch to symmetric division during aging