Table 4 Current CAR NK clinical trials listed on ClinicalTrials.Gov
From: Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy
Tumor type | Tumor type | Target antigen | NCT number | Types of NK cells | Status | Phase | Country |
|---|---|---|---|---|---|---|---|
ALL | Liquid | CD19 | NCT00995137 | Haploidentical donor NK cells | Completed | 1 | USA |
Solid tumors | Solid | NKG2D ligands | NCT03415100 | Autologous or allogeneic CAR NK cells targeting NKG2D ligands | Recruiting | 1 | China |
B-lymphoid malignancy, ALL, CLL, lymphoma | Liquid | CD19 | NCT03056339 | UCB NK cells | Recruiting | 1/2 | USA |
Multiple myeloma | Liquid | BCMA | NCT03940833 | NK-92 cells | Recruiting | 1/2 | China |
Solid tumors | Solid | ROBO1 | NCT03940820 | Unclear | Recruiting | 1/2 | China |
Pancreatic cancer | Solid | ROBO1 | NCT03941457 | Unclear | Recruiting | 1/2 | China |
Solid tumors | Solid | ROBO1 | NCT03931720 | Unclear | Recruiting | 1/2 | China |
Glioblastoma | Solid | HER2 | NCT03383978 | NK-92 cells | Recruiting | 1 | Germany |
B-cell acute lymphoblastic leukemia | Liquid | CD19 | NCT01974479 | Haploidentical donor NK cells | Suspended | 1 | Singapore |
AML | Liquid | CD33 | NCT02944162 | NK-92 cells | Recruiting | 1/2 | China |
Mantle cell, follicular, and B-cell lymphoma | Liquid | CD19 | NCT03579927 | UCB NK cells | Withdrawn | 1/2 | USA |
Refractory B-cell lymphoma | Liquid | CD22 | NCT03692767 | Unclear | Not yet recruiting | Early 1 | China |
Refractory B-cell lymphoma | Liquid | CD19 | NCT03690310 | Unclear | Not yet recruiting | Early 1 | China |
Ovarian cancer | Solid | Mesothelin | NCT03692637 | Unclear | Not yet recruiting | Early 1 | China |
Prostate cancer | Solid | PSMA | NCT03692663 | Unclear | Not yet recruiting | Early 1 | China |
Refractory B-cell lymphoma | Liquid | CD19, CD22 | NCT03824964 | Unclear | Not yet recruiting | Early 1 | China |
ALL, CLL, mantle cell and follicular lymphoma | Liquid | CD19 | NCT02892695 | NK-92 cells | Unknown | 1/2 | China |
ALL, T-cell leukemia and lymphoma | Liquid | CD7 | NCT02742727 | NK-92 cells | Unknown | 1/2 | China |
Hepatic, lung, pancreas, breast, colon, and gastric cancer | Solid | MUC1 | NCT02839954 | Unclear | Unknown | 1/2 | China |