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Table 4 Current CAR NK clinical trials listed on ClinicalTrials.Gov

From: Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Tumor type Tumor type Target antigen NCT number Types of NK cells Status Phase Country
ALL Liquid CD19 NCT00995137 Haploidentical donor NK cells Completed 1 USA
Solid tumors Solid NKG2D ligands NCT03415100 Autologous or allogeneic CAR NK cells targeting NKG2D ligands Recruiting 1 China
B-lymphoid malignancy, ALL, CLL, lymphoma Liquid CD19 NCT03056339 UCB NK cells Recruiting 1/2 USA
Multiple myeloma Liquid BCMA NCT03940833 NK-92 cells Recruiting 1/2 China
Solid tumors Solid ROBO1 NCT03940820 Unclear Recruiting 1/2 China
Pancreatic cancer Solid ROBO1 NCT03941457 Unclear Recruiting 1/2 China
Solid tumors Solid ROBO1 NCT03931720 Unclear Recruiting 1/2 China
Glioblastoma Solid HER2 NCT03383978 NK-92 cells Recruiting 1 Germany
B-cell acute lymphoblastic leukemia Liquid CD19 NCT01974479 Haploidentical donor NK cells Suspended 1 Singapore
AML Liquid CD33 NCT02944162 NK-92 cells Recruiting 1/2 China
Mantle cell, follicular, and B-cell lymphoma Liquid CD19 NCT03579927 UCB NK cells Withdrawn 1/2 USA
Refractory B-cell lymphoma Liquid CD22 NCT03692767 Unclear Not yet recruiting Early 1 China
Refractory B-cell lymphoma Liquid CD19 NCT03690310 Unclear Not yet recruiting Early 1 China
Ovarian cancer Solid Mesothelin NCT03692637 Unclear Not yet recruiting Early 1 China
Prostate cancer Solid PSMA NCT03692663 Unclear Not yet recruiting Early 1 China
Refractory B-cell lymphoma Liquid CD19, CD22 NCT03824964 Unclear Not yet recruiting Early 1 China
ALL, CLL, mantle cell and follicular lymphoma Liquid CD19 NCT02892695 NK-92 cells Unknown 1/2 China
ALL, T-cell leukemia and lymphoma Liquid CD7 NCT02742727 NK-92 cells Unknown 1/2 China
Hepatic, lung, pancreas, breast, colon, and gastric cancer Solid MUC1 NCT02839954 Unclear Unknown 1/2 China