TY - STD TI - Bao L, Deng W, Huang B, Gao H, Liu J, Ren L, et al. The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice. Nature. 2020; http://www.nature.com/articles/s41586-020-2312-y UR - http://www.nature.com/articles/s41586-020-2312-y ID - ref1 ER - TY - STD TI - Sungnak W, Huang N, Bécavin C, Berg M, Queen R, Litvinukova M, et al. SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes. Nat Med. 2020; http://www.nature.com/articles/s41591-020-0868-6 UR - http://www.nature.com/articles/s41591-020-0868-6 ID - ref2 ER - TY - STD TI - Merad M, Martin JC. Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol. 2020; http://www.nature.com/articles/s41577-020-0331-4 UR - http://www.nature.com/articles/s41577-020-0331-4 ID - ref3 ER - TY - JOUR AU - Kumar, H. AU - Kawai, T. AU - Akira, S. PY - 2009 DA - 2009// TI - Toll-like receptors and innate immunity JO - Biochem Biophys Res Commun VL - 388 UR - https://doi.org/10.1016/j.bbrc.2009.08.062 DO - 10.1016/j.bbrc.2009.08.062 ID - Kumar2009 ER - TY - JOUR AU - Kelley, N. AU - Jeltema, D. AU - Duan, Y. AU - He, Y. PY - 2019 DA - 2019// TI - The NLRP3 inflammasome: an overview of mechanisms of activation and regulation JO - Int J Mol Sci VL - 20 UR - https://doi.org/10.3390/ijms20133328 DO - 10.3390/ijms20133328 ID - Kelley2019 ER - TY - JOUR AU - Chen, I. -. Y. AU - Moriyama, M. AU - Chang, M. -. F. AU - Ichinohe, T. PY - 2019 DA - 2019// TI - Severe acute respiratory syndrome coronavirus Viroporin 3a activates the NLRP3 inflammasome JO - Front Microbiol UR - https://doi.org/10.3389/fmicb.2019.00050/full DO - 10.3389/fmicb.2019.00050/full ID - Chen2019 ER - TY - JOUR AU - Stiff, A. AU - Trikha, P. AU - Wesolowski, R. AU - Kendra, K. AU - Hsu, V. AU - Uppati, S. PY - 2016 DA - 2016// TI - Myeloid-derived suppressor cells express bruton’s tyrosine kinase and can be depleted in tumor-bearing hosts by ibrutinib treatment JO - Cancer Res VL - 76 UR - https://doi.org/10.1158/0008-5472.CAN-15-1490 DO - 10.1158/0008-5472.CAN-15-1490 ID - Stiff2016 ER - TY - JOUR AU - Benner, B. AU - Scarberry, L. AU - Stiff, A. AU - Duggan, M. C. AU - Good, L. AU - Lapurga, G. PY - 2019 DA - 2019// TI - Evidence for interaction of the NLRP3 inflammasome and Bruton’s tyrosine kinase in tumor-associated macrophages: implications for myeloid cell production of interleukin-1beta JO - Oncoimmunology. UR - https://doi.org/10.1080/2162402X.2019.1659704 DO - 10.1080/2162402X.2019.1659704 ID - Benner2019 ER - TY - JOUR AU - Ito, M. AU - Shichita, T. AU - Okada, M. AU - Komine, R. AU - Noguchi, Y. AU - Yoshimura, A. PY - 2015 DA - 2015// TI - Bruton’s tyrosine kinase is essential for NLRP3 inflammasome activation and contributes to ischaemic brain injury JO - Nat Commun VL - 6 UR - https://doi.org/10.1038/ncomms8360 DO - 10.1038/ncomms8360 ID - Ito2015 ER - TY - JOUR AU - Chen, G. AU - Wu, D. AU - Guo, W. AU - Cao, Y. AU - Huang, D. AU - Wang, H. PY - 2020 DA - 2020// TI - Clinical and immunological features of severe and moderate coronavirus disease 2019 JO - J Clin Invest [Internet] VL - 130 UR - https://doi.org/10.1172/JCI137244 DO - 10.1172/JCI137244 ID - Chen2020 ER - TY - JOUR AU - Huang, C. AU - Wang, Y. AU - Li, X. AU - Ren, L. AU - Zhao, J. AU - Hu, Y. PY - 2020 DA - 2020// TI - Clinical features of patients infected with 2019 novel coronavirus in Wuhan JO - China Lancet VL - 395 UR - https://doi.org/10.1016/S0140-6736(20)30183-5 DO - 10.1016/S0140-6736(20)30183-5 ID - Huang2020 ER - TY - STD TI - Roschewski M, Lionakis MS, Sharman JP, Roswarski J, Goy A, Monticelli MA, et al. Inhibition of Bruton tyrosine kinase in patients with severe COVID-19. Sci Immunol. 2020;5(48):eabd0110. https://doi.org/10.1126/sciimmunol.abd0110 ID - ref12 ER - TY - JOUR AU - He, L. AU - Ding, Y. AU - Zhang, Q. AU - Che, X. AU - He, Y. AU - Shen, H. PY - 2006 DA - 2006// TI - Expression of elevated levels of pro-inflammatory cytokines in SARS-CoV-infected ACE2 + cells in SARS patients: relation to the acute lung injury and pathogenesis of SARS JO - J Pathol VL - 210 UR - https://doi.org/10.1002/path.2067 DO - 10.1002/path.2067 ID - He2006 ER - TY - JOUR AU - Zhou, P. AU - Ma, B. AU - Xu, S. AU - Zhang, S. AU - Tang, H. AU - Zhu, S. PY - 2014 DA - 2014// TI - Knockdown of Burton’s tyrosine kinase confers potent protection against sepsis-induced acute lung injury JO - Cell Biochem Biophys VL - 70 UR - https://doi.org/10.1007/s12013-014-0050-1 DO - 10.1007/s12013-014-0050-1 ID - Zhou2014 ER - TY - JOUR AU - Porto, A. P. AU - Liu, Z. AU - Beer, R. AU - Florquin, S. AU - Boer, O. J. AU - Hendriks, R. W. PY - 2019 DA - 2019// TI - Btk inhibitor ibrutinib reduces inflammatory myeloid cell responses in the lung during murine pneumococcal pneumonia JO - Mol Med VL - 25 UR - https://doi.org/10.1186/s10020-018-0069-7 DO - 10.1186/s10020-018-0069-7 ID - Porto2019 ER - TY - JOUR AU - Florence, J. M. AU - Krupa, A. AU - Booshehri, L. M. AU - Davis, S. A. AU - Matthay, M. A. AU - Kurdowska, A. K. PY - 2018 DA - 2018// TI - Inhibiting Bruton’s tyrosine kinase rescues mice from lethal influenza-induced acute lung injury JO - Am J Physiol Cell Mol Physiol VL - 315 UR - https://doi.org/10.1152/ajplung.00047.2018 DO - 10.1152/ajplung.00047.2018 ID - Florence2018 ER - TY - STD TI - Treon SP, Castillo JJ, Skarbnik AP, Soumerai J, Ghobrial IM, Guerrera ML, et al. The BTK-inhibitor ibrutinib may protect against pulmonary injury in COVID-19 infected patients. Blood. 2020; ID - ref17 ER -