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Table 1 ER stress-regulated miRNAs and their potential roles in cancers

From: Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

Effectors Regulators Targets Cancer type Biological process References
miR-214 NA XBP-1 HCC Regulates HCC cell proliferation and apoptosis [73]
miR-199a-3p/5p NA NA HCC NA [73]
miR-1281 NA USP93 Osteosarcoma Promotes ER stress-mediated apoptosis [75]
miR-34a IRE1α MYC, cyclin D1, CDK4 AML Inhibition of IRE1α increases expression of miR-34a in AML cells [78]
miR-216b PERK c-Jun Osteosarcoma Sensitizes cells to ER stress-dependent apoptosis [79]
miR-211 PERK CHOP Osteosarcoma Inhibits circadian rhythm oscillations and ongoing protein synthesis [81]
miR-211 PERK CHOP Mammary tumors Regulates ER stress-dependent apoptosis [84]
miR-663 NA ZBTB7A Osteosarcoma Regulates ER stress-induced cell apoptosis [88]
miR-23a-3p NA PTEN AKT HCC Upregulates macrophage PD-L1 expression and inhibits T cell function, which promotes tumor cells to escape immune surveillance [115]
miR-765 NA FOXA2 Melanoma Enhances tumor stem cell renewal and apoptosis inhibition [120]
miR-663 NA TGFB1 HCC Regulates ER stress-induced apoptosis [184]
miR-221/222 NA NA HCC Promotes ER stress-mediated apoptosis [185]
miR-346 XBP1 TAP1 Cervical cancer Reduces MHC class I-associated antigen presentation [186]
  1. NA, not available; HCC, hepatocellular carcinoma; AML, acute myeloid leukemia