Table 1 ER stress-regulated miRNAs and their potential roles in cancers
From: Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer
Effectors | Regulators | Targets | Cancer type | Biological process | References |
|---|---|---|---|---|---|
miR-214 | NA | XBP-1 | HCC | Regulates HCC cell proliferation and apoptosis | [73] |
miR-199a-3p/5p | NA | NA | HCC | NA | [73] |
miR-1281 | NA | USP93 | Osteosarcoma | Promotes ER stress-mediated apoptosis | [75] |
miR-34a | IRE1α | MYC, cyclin D1, CDK4 | AML | Inhibition of IRE1α increases expression of miR-34a in AML cells | [78] |
miR-216b | PERK | c-Jun | Osteosarcoma | Sensitizes cells to ER stress-dependent apoptosis | [79] |
miR-211 | PERK | CHOP | Osteosarcoma | Inhibits circadian rhythm oscillations and ongoing protein synthesis | [81] |
miR-211 | PERK | CHOP | Mammary tumors | Regulates ER stress-dependent apoptosis | [84] |
miR-663 | NA | ZBTB7A | Osteosarcoma | Regulates ER stress-induced cell apoptosis | [88] |
miR-23a-3p | NA | PTEN AKT | HCC | Upregulates macrophage PD-L1 expression and inhibits T cell function, which promotes tumor cells to escape immune surveillance | [115] |
miR-765 | NA | FOXA2 | Melanoma | Enhances tumor stem cell renewal and apoptosis inhibition | [120] |
miR-663 | NA | TGFB1 | HCC | Regulates ER stress-induced apoptosis | [184] |
miR-221/222 | NA | NA | HCC | Promotes ER stress-mediated apoptosis | [185] |
miR-346 | XBP1 | TAP1 | Cervical cancer | Reduces MHC class I-associated antigen presentation | [186] |