Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

Table 3 MiRNAs directly or indirectly regulate UPR pathway components

Regulators	Effectors	Targets	Cancer type	Biological process	Reference
miR-233	HSP70	HSPA1A	Osteosarcoma	Regulates apoptosis	[25]
miR-216b	CHOP	c-JUN	Osteosarcoma	Sensitizes cells to apoptosis	[79]
miR-30c-2*	XBP1	XBP1	Cervical cancer	Influences the fate of cells challenged with ER stress	[80]
miR-657	CHOP	NA	Hematological cancer	Attenuates the expression of CHOP, p-ATF2, and PARP cleavage to reverse SSD-induced apoptosis	[91]
miR-211	CHOP	NA	Lymphoma, multiple myeloma	Attenuates COM-induced apoptosis	[92]
miR-34c	eIF2α CHOP IRE1α	HMGB1	NSCLC	Inhibits cell proliferation, promotes apoptosis, and induces ER stress in NSCLC cells	[93]
miR-451a	GRP78 PERK elF2α ATF4 CHOP	BAP31	Colorectal cancer	Inhibits proliferation and increases apoptosis	[98]
miR-410	CHOP GRP94 GRP78 eIF2α	ERLIN2	Breast cancer	Inhibits cell migration and invasion and EMT	[108]
miR-224 miR-520c	ATF6α	TUSC3	NSCLC	Enhances UPR and ERAD to promote metastatic potential of	[109]
miR-122	GRP78 CHOP	CDK4	HCC	Regulates anticancer drug–mediated apoptosis	[167]
miR-146a	CHOP	CHOP	Lung cancer	Reduces the sensitivity of lung cancer cells to cisplatin	[171]
miR-7112-3p	PERK	PERK	Colorectal cancer	Enhances apoptosis in CX-1 cells treated with DVDMS-PDT	[174]
miR-1202	GRP78	Rab1A	Glioma	Inhibits proliferation and induces ER stress and apoptosis	[187]
miR-15b-5p	GRP78	Rab1A	HCC	Induces apoptosis	[188]
miR-1291	IRE1α	IRE1α	HCC	Regulates glypican-3 mRNA expression	[189]
miR-30d miR-181a miR-199a-5p	GRP78	GRP78	Prostate cancer	Suppresses GRP78 levels and GRP78-mediated chemoresistance	[190]

NA, not available; NSCLC, non-small cell lung cancer; HCC, hepatocellular carcinoma

ISSN: 1756-8722