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Table 4 LncRNAs regulate UPR pathway components

From: Interplay between endoplasmic reticulum stress and non-coding RNAs in cancer

LncRNAs Expression level Tumor type UPR-related mechanism Biological process References
MEG3   Breast cancer Increases ER stress-related proteins (GRP78, IRE1, PERK, ATF6, and CHOP) and NF-κB Inhibits growth, induces apoptosis [121]
Downregulated ESCC Increases ER stress-related proteins (GRP78, IRE1, PERK, ATF6, and CHOP), caspase-9, and cleaved caspase-3 Inhibits cell growth, induces apoptosis [122]
Downregulated HCC Increases ER stress-related proteins (GRP78, IRE1, PERK, ATF6, and CHOP) Inhibits proliferation, induces apoptosis [123]
Downregulated Cervical carcinoma Competing endogenous RNA of miR-7-5p Accelerate ER stress-mediated apoptosis [124]
Downregulated Colorectal carcinoma Increases ER stress-related proteins (GRP78, ATF6, and CHOP) Suppresses proliferation and invasion [125]
CASC2 Downregulated NSCLC Increases PERK mRNA stability Promotes radiation-induced apoptosis [127]
FOXD3-AS1 Upregulated NPC Silencing FOXD3-AS1 promotes ER stress-induced apoptosis by competitively binding to let-7e-5p Silencing of FOXD3-AS1 induces apoptosis [128]
LincRNA-p21 Downregulated HCC Induces expression of IRE1, CHOP, and GRP78 and upregulates the phosphorylation level of PERK Contributes to sorafenib-induced ER stress and apoptosis [132]
NORAD Upregulated Melanoma Knockdown of NORAD can inhibit UPR-related genes including GRP78, CHOP, and eIF2α Promotes invasion and migration [136]
NEAT1 Upregulated Multiple myeloma Promotes expression of UPR-related proteins CHOP, XBP-1, and IRE1 Promotes proliferation, migration, and invasion [141]
LUCRC Upregulated Colorectal cancer Induces the expression of GRP78 Promotes proliferation, migration, and invasion [142]
OR3A4 Upregulated Osteosarcoma Knockdown of OR3A4 inhibits the expression of G6PD, blocking the pentose phosphate pathway and resulting in ER-stress Promotes proliferation, colony formation [145]
  1. ESCC, esophageal squamous cell carcinoma; HCC, hepatocellular carcinoma; NSCLC, non-small cell lung cancer; NPC, nasopharyngeal carcinoma