Fig. 3

Activation of the FAK signalling pathway mediates acquired EGFR-TKI resistance in NSCLC. a, b Activity of protein kinases in PC9, PC9GR, HCC827, and HCC827GR cells using kinome-wide array analysis. c Western blotting was used to analyse expression of p-FAK, p-SRC, p-AKT, and p-ERK in HCC827, HCC827GR, PC9, and PC9GR cells. d Expression of p-FAK, p-AKT and p-ERK in PC9GR cells transfected with si-ITGAV or si-ITGB3 was detected by western blot analysis