Fig. 6

Inhibition of the FAK signalling pathway increases sensitivity to EGFR-TKIs in PC9 cells. a The sensitivity of PC9GR cells treated with VS-6063 to gefitinib was determined by CCK-8 assays. b The effect of gefitinib combined with VS-6063 treatment on the proliferation of PC9GR cells. c Fluorescence-activated cell sorting (FACS) analysis was performed to investigate the effects of gefitinib combined with VS-6063 treatment on apoptosis in PC9GR cells. d Western blot analysis was used to detect the effect of gefitinib combined with VS-6063 treatment on CyclinD1 and PARP in PC9GR cells. e Under gefitinib treatment, p-FAK, p-AKT and p-ERK levels in PC9 cells transfected with si-FAK or si-NC were detected by western blot analysis (**P < 0.01; ***P < 0.001)