Table 1 Distribution proportion of 3 groups of BRCA1 variants carriers clinical characteristics
Variables | Re-Pathogenic | VUS | P1-value | Re-Benign | P2-value |
|---|---|---|---|---|---|
No. of subjects | 38 | 101 | 58 | ||
Age at entry | 46.47 | 47.96 | 49.01 | ||
Age at diagnosis | 44.76 | 46.27 | 47.22 | ||
Early onset breast cancer | 36.84% (14/38) | 26.73% (27/101) | 0.516 | 20.69% (12/58) | 0.630 |
Location of cancer (both sides/one side) | 0 (0/23) | 1.47% (1/68) | 1 | 2.38% (1/42) | 1 |
Luminal A breast cancer | 0 (0/28) | 8.57% (6/70) | 0.290 | 13.51% (5/37) | 0.699 |
Luminal B breast cancer | 42.86% (12/28) | 50% (35/70) | 0.853 | 54.05% (20/37) | 0.959 |
Triple negative breast cancer | 50% (14/28) | 34.29% (24/70) | 0.465 | 24.32% (9/37) | 0.569 |
HER2-positive breast cancer | 7.14% (2/28) | 7.14% (5/70) | 1 | 8.11% (3/37) | 1 |
Family history of breast cancer | 15.79% (6/38) | 8.91% (9/101) | 0.465 | 5.17% (3/58) | 0.626 |
Family history of other cancers | 18.42% (7/38) | 15.84% (16/101) | 0.956 | 15.52% (9/58) | 1 |