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Table 1 Tumor-associated antigen expression (MFI, mean fluorescence intensity) in osteosarcoma

From: GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma

Cell line Isotype control GD2 GD3 HER2 B7H3 (CD276) HMW-M CSPG4 GPA33 L1CAM GPC-3 Lewis Y PSA Globo H IL-11Ra PD-L1 PSMA IGF2R
Osteosarcoma                 
 143B 5 64 9 32 261 83 6 24 6 16 8 7 14 36 6 7
 U-2 OS 5 135 10 75 255 124 5 49 15 41 7 8 18 44 5 8
 MG-63 5 45 10 30 346 66 6 24 8 18 14 6 7 89 5 8
 HOS 5 11 11 38 268 40 8 21 14 27 10 7 18 69 5 8
 Saos-2 5 9 6 54 357 37 8 23 14 43 10 6 22 124 5 10
 hFOB1.19 5 10 6 76 724 55 5 40 8 38 6 6 17   5  
Neuroblastoma                 
 IMR32 5 1468               
 LAN-1 5 1625               
 BE(2)C 5 1005               
Breast cancer                 
 HCC1594 5    2091             
 SKBR3 5    2506             
 AU565 5    1175             
  1. GD2, disialoganglioside GD2; GD3, disialohematoside; HER2, human epidermal growth factor receptor 2; HMW, high molecular weight melanoma antigen; CSPG4, chondroitin-sulfate proteoglycan 4; GPA, glycoprotein A33; L1CAM, L1 cell adhesion molecule; GPC-3, glypican-3; PSA, polysialic acid; PD-L1, programmed death-ligand 1; PSMA, prostate-specific membrane antigen; IGF2R; insulin-like growth factor 2 receptor