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Table 1 Tumor-associated antigen expression (MFI, mean fluorescence intensity) in osteosarcoma

From: GD2 or HER2 targeting T cell engaging bispecific antibodies to treat osteosarcoma

Cell line

Isotype control

GD2

GD3

HER2

B7H3 (CD276)

HMW-M CSPG4

GPA33

L1CAM

GPC-3

Lewis Y

PSA

Globo H

IL-11Ra

PD-L1

PSMA

IGF2R

Osteosarcoma

                

 143B

5

64

9

32

261

83

6

24

6

16

8

7

14

36

6

7

 U-2 OS

5

135

10

75

255

124

5

49

15

41

7

8

18

44

5

8

 MG-63

5

45

10

30

346

66

6

24

8

18

14

6

7

89

5

8

 HOS

5

11

11

38

268

40

8

21

14

27

10

7

18

69

5

8

 Saos-2

5

9

6

54

357

37

8

23

14

43

10

6

22

124

5

10

 hFOB1.19

5

10

6

76

724

55

5

40

8

38

6

6

17

 

5

 

Neuroblastoma

                

 IMR32

5

1468

              

 LAN-1

5

1625

              

 BE(2)C

5

1005

              

Breast cancer

                

 HCC1594

5

  

2091

            

 SKBR3

5

  

2506

            

 AU565

5

  

1175

            
  1. GD2, disialoganglioside GD2; GD3, disialohematoside; HER2, human epidermal growth factor receptor 2; HMW, high molecular weight melanoma antigen; CSPG4, chondroitin-sulfate proteoglycan 4; GPA, glycoprotein A33; L1CAM, L1 cell adhesion molecule; GPC-3, glypican-3; PSA, polysialic acid; PD-L1, programmed death-ligand 1; PSMA, prostate-specific membrane antigen; IGF2R; insulin-like growth factor 2 receptor
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Journal of Hematology & Oncology

ISSN: 1756-8722

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