Table 1 NK cell receptors and their ligands in human

NK activating receptor

NKG2D

MHC class I chain-related protein A (MICA) and B (MICB), UL16-binding proteins (ULBP1-6)

DNAM1

PVR(CD155), nectin-2 (CD112)

NKp30 (NCR3)

pp65, B7-H6, galectin-3, BAG6, viral hemagglutinin (HA), heparan sulfate (HS) glycosaminoglycans (GAGs), (DBL)-1a domain of Plasmodium falciparum erythrocyte membrane protein-1

NKp44 (NCR2)

PDGF-DD, 21spe-MLL5, PCNA, Syndecan-4, Nidogen-1, viral HA, HS GAGs

NKp46 (NCR1)

Complement factor P, viral HA, HS GAGs, (DBL)-1a domain of Plasmodium falciparum erythrocyte membrane protein-1, vimentin

CD16 (FcγRIII)

Fc portion of IgG antibodies

NK inhibitory receptors

CD94/NKG2A

HLA-E

KIR2DL1

HLA-C, group 2

KIR2DL2/3

HLA-C, group 1

KIR3DL1

HLA-Bw4

KIR3DL2

HLA-A3, A11