Fig. 11

The toxicity study of compound 13 by oral administration at a dose of 500 mg/kg. a The level of GPT, GOT and Cr in serum after oral administration of 13 for 72 h in Bar b/c mice. b The organ coefficient of liver, spleen, lung, brain, heart and kidney were calculated. The organ coefficient was calculated by organ weight divided by body weight. c The histomorphology of liver, spleen, brain, kidney, lung, spleen and heart were analyzed by HE staining