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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Fig. 3

DMOCPTL induced apoptosis and ferroptosis of TNBC cells. a The percentage of cell viability after the combination of DMOCPTL (0.5 μM) with necrosis inhibitor necrostatin-1 (10 μM) for 72 h. b The percentage of cell viability after the combination of DMOCPTL (0.5 μM) with 3-methyladenine (5 mM) for 72 h. c The percentage of cell viability after the combination of DMOCPTL (0.5 μM) with Z-VAD-FMK (10 μM) for 72 h. d The percentage of cell viability after the combination of DMOCPTL (0.5 μM) with ferroptosis inhibitors N-Acetyl-L-cysteine (5 mM), e deferoxamine (200 μM), and f Ferrostatin-1 (10 μM). Analysis results represented mean ± SD, **P < 0.01, ***P < 0.001

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