Fig. 7
Clinical relevance of HOMER3-induced β-Catenin activation in breast cancer. a, b Representative images (a) and correlation analysis (b) of HOMER3 and nuclear β-Catenin staining in 347 breast cancer specimens. χ2 test was used. c The patient specimens were divided into three groups according to HOMER3 and nuclear β-Catenin expression. Kaplan–Meier survival curves showed that breast cancer patients with combined high HOMER3 and nuclear β-Catenin significantly suffered the worst DMFS and OS. d Study model: HOMER3 provides a scaffold platform to promote Tyr phosphorylation and activation of β-Catenin, leading to the malignant progression and poor clinical outcomes in human breast cancer