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Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: Targeting B7-H3 via chimeric antigen receptor T cells and bispecific killer cell engagers augments antitumor response of cytotoxic lymphocytes

Fig. 3

Therapeutic effects of B7-H3 CAR-T cells in tumor xenografts. a Treatment scheme of B7-H3 CAR-T cells in A549 or HCT 116 xenograft models. be Tumor growth in A549-injected mice b or HCT 116-injected mice c was measured using digital caliper, and tumor area was calculated (n = 5). Mean values per treatment group are shown. The p values of treatment were analyzed using ANOVA. Survival curves of A549-injected mice d or HCT 116-injected mice e are shown. The p values of survival curves were analyzed using the log-rank (Mantel–Cox) test. Data are presented as the mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001. f H&E staining of major organs in mice treated with CAR-T cells. g  Tumor infiltration of B7-H3 CAR-T cells in A549-injected mice. On days 1 and 2, the tumors were harvested, sliced, fixed and imaged in the fluorescence microscope. Representative images are shown. ZsGreen is used as the reporter of CAR-T cells. Representative images are shown

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