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Table 2 Impact of response dichotomy on the sample size required to achieve the target power by study duration. Target power is 80%. Lag duration is 1 month. Hazard ratio for responding patients is 0.3. Enrollment rate is 0.53 subjects/day

From: Treating non-responders: pitfalls and implications for cancer immunotherapy trial design

p (%)Sample size required to achieve the target power
Study duration
3 years4 years5 years
20NA313269
30186153137
401089689
50767068
60555252