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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Clonal evolution in liver cancer at single-cell and single-variant resolution

Fig. 2

Genetic and phenotypic heterogeneity are showing consistence in liver cancer. a Cell clusters in scRNA-Seq analysis. b Heatmap showing patient-specific tumor marker genes. c The expression patterns of representative markers. d Copy number changes inferred from global transcriptomic profile of single cells in HCC9, with boxes highlighting sub-populations. e Heatmap (left) and t-SNE plot (right) showing the sub-populations in HCC9 based on differentially expressed genes. f The expression patterns of genes mutated in each HCC sample in scRNA-Seq data. Genes were grouped by tissue origin in the upper panel, and clustered by expression patterns in the lower panel

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