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Table 1 Some representative registered clinical trials of MSC therapies

From: Challenges and advances in clinical applications of mesenchymal stromal cells

NCT Number

Title

Phase

Sponsor/Collaborators

NCT02097641

Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START)

Phase 2

National Heart, Lung, and Blood Institute (NHLBI)

Massachusetts General Hospital

Stanford University

University of Pittsburgh

University of Minnesota

Ohio State University

University of California, San Francisco

NCT00957931

Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs

Phase 2

Stanford University

University of Minnesota

University of Alabama at Birmingham

NCT01771913

Immunophenotyping of Fresh Stromal Vascular Fraction From Adipose-Derived Stem Cells (ADSC) Enriched Fat Grafts

Phase 2

University of Sao Paulo

NCT01909154

Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia (CME-LEM1)

Phase 1

Puerta de Hierro University Hospital

NCT03102879

Encapsulated Mesenchymal Stem Cells for Dental Pulp Regeneration

Phase 1

Phase 2

Universidad de los Andes, Chile

Cells for Cells, Chile

NCT02467387

A Study to Assess the Effect of Intravenous Dose of (aMBMC) to Subjects With Non-ischemic Heart Failure

N/A

CardioCell LLC

Stemedica Cell Technologies, Inc

NCT02387749

Effect Of Mesenchymal Stem Cells Transfusion on the Diabetic Peripheral Neuropathy Patients

N/A

Cairo University

NCT01932164

Use of Mesenchymal Stem Cells for Alveolar Bone Tissue Engineering for Cleft Lip and Palate Patients

N/A

Hospital Sirio-Libanes

NCT02481440

Repeated Subarachnoid Administrations of hUC-MSCs in Treating SCI

Phase 1

Phase 2

Third Affiliated Hospital, Sun Yat-Sen University, China

NCT02165904

Subarachnoid Administrations of Adults Autologous Mesenchymal Stromal Cells in SCI

Phase 1

Emory University

NCT02330978

Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma

Phase 1

University of Sao Paulo

NCT01183728

NCT01586312

Treatment of Knee Osteoarthritis With Autologous/ Allogenic Mesenchymal Stem Cells

Phase 1

Phase 2

Red de Terapia Celular

Fundacion Teknon, Centro Medico Teknon, Barcelona

University of Valladolid

NCT02037204

IMPACT: Safety and Feasibility of a Single-stage Procedure for Focal Cartilage Lesions of the Knee

Phase 1

Phase 2

UMC Utrecht

NCT02958267

Investigation of Mesenchymal Stem Cell Therapy for the Treatment of Osteoarthritis of the Knee

Phase 2

OhioHealth

NCT00587990

Prospective Randomized Study of Mesenchymal Stem Cell Therapy in Patients Undergoing Cardiac Surgery (PROMETHEUS)

Phase 1

Phase 2

National Heart, Lung, and Blood Institute (NHLBI)

Johns Hopkins University Specialized Center for Cell Based Therapy

The Emmes Company, LLC

University of Miami

NCT01385644

A Study to Evaluate the Potential Role of Mesenchymal Stem Cells in the Treatment of Idiopathic Pulmonary Fibrosis

Phase 1

The Prince Charles Hospital

Mater Medical Research Institute

NCT02509156

Stem Cell Injection in Cancer Survivors

Phase 1

The University of Texas Health Science Center, Houston

National Heart, Lung, and Blood Institute (NHLBI)

NCT02379442

Early Treatment of Acute Graft Versus Host Disease With Bone Marrow-Derived Mesenchymal Stem Cells and Corticosteroids

Phase 1

Phase 2

National Heart, Lung, and Blood Institute (NHLBI)

National Institutes of Health Clinical Center (CC)

NCT01087996

The Percutaneous Stem Cell Injection Delivery Effects on Neomyogenesis Pilot Study (The POSEIDON-Pilot Study)

Phase 1

Phase 2

University of Miami

National Heart, Lung, and Blood Institute (NHLBI)

The Emmes Company, LLC

NCT02013674

The TRansendocardial Stem Cell Injection Delivery Effects on Neomyogenesis Study (The TRIDENT Study)

Phase 2

The Emmes Company, LLC

University of Miami

NCT01392625

PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study)

Phase 1

Phase 2

National Heart, Lung, and Blood Institute (NHLBI)

University of Miami

NCT00768066

The Transendocardial Autologous Cells (hMSC or hBMC) in Ischemic Heart Failure Trial (TAC-HFT)

Phase 1

Phase 2

University of Miami

The Emmes Company, LLC

NCT00629018

Safety and Efficacy Study of Stem Cell Transplantation to Treat Dilated Cardiomyopathy

Phase 2

University Medical Centre Ljubljana

Blood Transfusion Centre of Slovenia

Stanford University

NCT00927784

Effect of Intramyocardial Injection of Mesenchymal Precursor Cells on Heart Function in People Receiving an LVAD

Phase 2

Icahn School of Medicine at Mount Sinai

National Heart, Lung, and Blood Institute (NHLBI)

Angioblast Systems

  1. N/A, not applicable