From: Challenges and advances in clinical applications of mesenchymal stromal cells
Abbreviation | Names | Functional description | References |
---|---|---|---|
HMGB1 | High Mobility Group Box 1 | Interacts with SDF-1 and CXCR4; required for tissue repairment | [30] |
KLF2 | Krüppel-like Factor 2 | Enhances MSC proliferation; required for the maintenance of stemness | [31] |
MCM2 | Minichromosome maintenance marker 2 | Required for cell division and DNA replication | [32] |
CCNA2 | Cyclin A2 | Regulates cell cycle | [33] |
PCNA | Proliferating cell nuclear antigen | Recruits and retains many enzymes required for DNA replication and repairment | [34] |
POLA1 | DNA Polymerase Alpha 1 | Required for DNA replication | [35] |
POLD1 | DNA Polymerase Delta 1 | Required for DNA replication | [36] |
RFC4 | replication factor C subunit 4 | Required for DNA replication | [37] |
MAD2L1 | mitotic arrest-deficient 2 like 1 | Executes mitotic checkpoint | [38] |
CDK1 | Cyclin-Dependent Kinase 1 | A catalytic subunit of a protein kinase complex that induces cell entry into mitosis | [39] |
CCNB1 | Cyclin B1 | Predominantly expressed in the G2/M phase of cell division | [40] |
CDC45 | Cell Division Cycle 45 | An important component of the replication fork, in DNA unwinding | [41] |
TUBA1B | Tubulin Alpha 1b | Mitosis, cell movement, intracellular movement, and other biological processes | [42] |
E2F1 | E2F Transcription Factor 1 | Promotes proliferation or apoptosis in response to DNA damage | [43] |
BIRC5 | Baculoviral IAP Repeat Containing 5 | Regulates apoptosis | [44] |
BLM | Bloom syndrome, RecQ helicase-like | Maintains genome integrity | [45] |
ITGAV | Integrin Subunit Alpha V | Belongs to α-V integrin family, required for cell surface adhesion | [46] |
MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A | Required for chromosomes alignment at metaphase plate | [47] |