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Table 7 The registered clinical trials of treatment using EVs or exosomes derived from MSCs

From: Challenges and advances in clinical applications of mesenchymal stromal cells

NCT number

Title

Status

Condition

Phase

Start date

NCT04173650

MSC EVs in Dystrophic Epidermolysis Bullosa

Not yet recruiting

Dystrophic Epidermolysis Bullosa

Phase 1

Phase 2

Sep-2020

NCT04276987

A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia

Completed

Coronavirus

Phase 1

Feb-2020

NCT02138331

Effect of Microvesicles and Exosomes Therapy on cell Mass in Type I Diabetes Mellitus (T1DM)

Unknown status

Diabetes Mellitus Type 1

Phase 2

Phase 3

Apr-2014

NCT04313647

A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers

Recruiting

Healthy

Phase 1

Mar-2020

NCT03384433

Allogenic Mesenchymal Stem Cell-Derived Exosome in Patients With Acute Ischemic Stroke

Recruiting

Cerebrovascular Disorders

Phase 1

Phase 2

Apr-2019

NCT04223622

Effects of ASC Secretome on Human Osteochondral Explants

Not yet recruiting

Osteoarthritis

-

Feb-2020

NCT04213248

Effect of UMSCs-Derived Exosomes on Dry Eye in Patients With cGVHD

Recruiting

Dry Eye

Phase 1

Phase 2

Feb-2020

NCT03437759

MSC-Exos Promote Healing of MHs

Recruiting

Macular Holes

Early Phase 1

Mar-2017

NCT04356300

Exosome of Mesenchymal Stem Cells for Multiple Organ Dysfunction Syndrome After Surgical Repair of Acute Type A Aortic Dissection

Not yet recruiting

Multiple Organ Failure

Not Applicable

Sep-2020

NCT04388982

The Safety and the Efficacy Evaluation of Allogenic Adipose MSC-Exos in Patients With Alzheimer's Disease

Recruiting

Alzheimer Disease

Phase 1

Phase 2

Jul-2020

NCT03608631

Exosomes in Treating Participants with Metastatic Pancreas Cancer with KrasG12D Mutation

Not yet recruiting

Metastatic Pancreatic Adenocarcinoma|Pancreatic Ductal Adenocarcinoma|Stage IV Pancreatic Cancer

Phase 1

Mar-2020

NCT04602442

Safety and Efficiency of Method of Exosome Inhalation in COVID-19 Associated Pneumonia

Enrolling by invitation

Covid19

Phase 2

Oct-2020

NCT04491240

Evaluation of Safety and Efficiency of Method of Exosome Inhalation in SARS-CoV-2 Associated Pneumonia

Completed

Covid19

Phase 1

Phase 2

July 2020

NCT04602104

A Clinical Study of Mesenchymal Stem Cell Exosomes Nebulizer for the Treatment of ARDS

Not yet recruiting

Acute Respiratory Distress Syndrome

Phase 1

Phase 2

Oct-2020

NCT03857841

A Safety Study of IV Stem Cell-derived Extracellular Vesicles (UNEX-42) in Preterm Neonates at High Risk for BPD

Recruiting

Bronchopulmonary Dysplasia

Phase 1

June-2019