Table 8 MSCs therapies for COVID-19 in clinical trials
From: Challenges and advances in clinical applications of mesenchymal stromal cells
Study name | NCT number | Starting date | Phase | Key findings/study status |
|---|---|---|---|---|
Mesenchymal Stem Cell Therapy for SARS-CoV-2-related Acute Respiratory Distress Syndrome | NCT04366063 | April 2020 | 2–3 | Recruiting |
UC-MSCs in the treatment of novel coronavirus severe pneumonia | NCT04273646 | February 2020 | Not applicable | Not yet recruiting |
A pilot clinical study on inhalation of MSCs exosomes treating severe novel coronavirus pneumonia | NCT04276987 | February 2020 | 1 | Not yet recruiting |
UC-MSCs treatment for the 2019-novel coronavirus pneumonia | NCT04269525 | February 2020 | 2 | Recruiting |
Treatment with MSCs for severe corona virus disease 2019 | NCT04288102 | February 2020 | 1–2 | Not yet recruiting |
MSCs treatment for pneumonia patients infected with 2019 novel coronavirus | NCT04252118 | January 2020 | 1 | Recruiting |
Nest Cell ®Mesenchymal Stem Cell to Treat Patients with Severe COVID19 Pneumonia | NCT04315987 | April 2020 | 1 | Not yet recruiting |
Treatment of COVID19 Patients Using Wharton’s Jelly Mesenchymal Stem Cells | NCT04313322 | March 2020 | 1 | Recruiting |
Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells | NCT04302519 | March 2020 | Early phase 1 | Not yet recruiting |
Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID19 Patients | NCT04336254 | April 2020 | 1 and 2 | Recruiting |
Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID19 Pneumonia | NCT04339660 | February 2020 | 1 and 2 | Recruiting |
Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Severe Patients With Coronavirus Disease 2019 (COVID19) | NCT04346368 | April 2020 | 1 and 2 | Not yet recruiting |
Adipose Mesenchymal Cells for Abatement of SARS CoV-2 Respiratory Compromise in COVID-19 Disease | NCT04352803 | April 2020 | 1 | Not yet recruiting |
A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HBadMSCs) to Provide Protection Against COVID19 | NCT04349631 | May 2020 | 2 | Enrolling by invitation |
Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) (COVID19) (REALIST) | NCT03042143 | January 2019 | 1 and 2 | Recruiting |
Safety and Efficacy of Intravenous Wharton’s Jelly-Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome due to COVID19 | NCT04390152 | June 2020 | 1 and 2 | Not yet recruiting |
Treatment of COVID19 Associated Pneumonia with Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells | NCT04382547 | May 2020 | 1 and 2 | Not yet recruiting |
Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients with Severe Pneumonia due to COVID19 | NCT04366323 | April 2020 | 1 and 2 | Not yet recruiting |
Study of the Safety of Therapeutic Tx with Immunomodulatory MSC in Adults with COVID19 Infection Requiring Mechanical Ventilation | NCT04397796 | June 2020 | 1 | Not yet recruiting |
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients with Respiratory Distress to COVID19 | NCT04390139 | May 2020 | 1 and 2 | Recruiting |
Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID19) Induced Acute Respiratory Distress Syndrome | NCT04377334 | May 2020 | 2 | Not yet Recruiting |
Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID19 | NCT04362189 | May 2020 | 3 | Not yet Recruiting |
Clinical Trial of Allogeneic Mesenchymal Cells from Umbilical Cord Tissue in Patients with COVID19 | NCT04366271 | May 2020 | 2 | Recruiting |
A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Allogeneic Mesenchymal Stem Cell Therapy (HBadMSCs) to Provide Protection Against COVID19 | NCT04348435 | April 2020 | 2 | Enrolling by invitation |
Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019 | NCT04371601 | March 2020 | 2 | Active not Recruiting |
Use of UC-MSCs for COVID19 Patients | NCT04355728 | April 2020 | Early Phase 1 | Recruiting |
Clinical Use of Stem Cells for the Treatment of COVID19 | NCT04392778 | April 2020 | 1 and 2 | Recruiting |
Study of the Safety of Therapeutic Tx with Immunomodulatory MSC in Adults with COVID19 Infection Requiring Mechanical Ventilation | NCT04397796 | June 2020 | 1 and 2 | Not yet Recruiting |
Efficacy and Safety Evaluation of Mesenchymal Stem Cells for the Treatment of Patients with Respiratory Distress to COVID19 | NCT04390139 | May 2020 | 1 | Recruiting |