Skip to main content

Table 2 Mutations induced FGFR-TKIs resistance

From: FGFR-TKI resistance in cancer: current status and perspectives

TKI classification

TKI name

Mutation in kinase

Pan-FGFR inhibitors

TAS-120

FGFR2(V564F)

Multi-kinase inhibitors

TKI258

FGFR1(N546K); FGFR2(V564I,M536I,M538I,I548V,L618M,E719G,E565,K462,N550)

Ponatinib

FGFR1(N546K); FGFR2(V564I); FGFR4(V550 E/L)

E3810

FGFR1(V561M)

Selective FGFR inhibitors

AZD4547

FGFR1(V561M); FGFR2(I567, N568, V581, E584G, S587,K660E, K678M); FGFR3(V555M)

BGJ398

FGFR2(N550H/K, V564F, E565A, K660M, L618V, K641R)

PD173074

FGFR1(V561M, N546H); FGFR3(V555M)

AZ12908010

FGFR3(V555M)

Debio 1347

FGFR2(N550K, K660M, L618V)

BLU-554

FGFR4(V550M/L, C552)