Table 1 The roles of KDM5A in homeostasis

Preadipocytes

C/EBPβ blocks Wnt/β-catenin activity in a demethylase-dependent fashion and represses Wnt6 transcription

Promoting preadipocyte differentiation

[75]

Reprogramming-resistant fibroblast

KDM5A transcriptionally inhibits OCT4 expression

Inhibiting reprogramming efficiency

[71]

Mouse embryonic stem cells

KDM5A transcriptionally inhibits cell cycle genes

Repressing cell differentiation

[74,75,76]

Heart

KDM5A interacts with CLOCK-BMAL1 to bind to the Per2 promoter, increasing histone acetylation and enhancing transcription in a demethylase-independent fashion

Activating CLOCK-BMAL1 and affecting the circadian clock

[77]

Natural killer cells

KDM5A mediates NK cell activation through interacting with p50 to inhibit SOCS1

Activating NK cells

[79]

IMR-90 cells

KDM5A contributes to retinoblastoma-mediated gene silencing

Mediating cellular senescence

[78]

Drosophila

KDM5 regulates immune control and gut microbiota maintenance

Regulating social behavior

[81]