Table 2 The functional roles of KDM5A in cancer

Acute myeloid leukemia

KDM5A forms fused gene with NUP98 and maintains expression of the Hoxa gene cluster via specifically binding their promoters

Blocking genetic program required for normal cellular differentiation

[5, 51, 90, 91]

Breast cancer

KDM5A transcriptionally inhibits expression of p16, p27, and Bak-1, and induces ITGB1 expression

Promoting cancer proliferation, drug tolerance, and metastasis

[5, 9, 12, 23, 29, 92,93,94]

Prostate cancer

KDM5A decrease the levels of two tumor suppression and differentiation genes KLF4 and E-cadherin

Leading to malignancy of PCs

[95,96,97,98]

Glioblastoma

KDM5A promotes cell proliferation, self-renewal, and drug resistance of GBM by regulating Hoxa-9 and -10 and transcription factor FOXM; it promotes migration and invasion of glioma cells via downregulating ZEB1

Promoting proliferation, self-renewal, and drug resistance of GBM and inhibiting the migration and invasion of glioma cells

[4, 99, 100]

Lung cancer

KDM5A inhibiting the expression of p27 and TFPI2, and upregulating cyclin D1, and ITGB1; it promotes angiogenesis and EMT via Akt signaling

Facilitating proliferation, motility, migration, invasion, metastasis, and drug resistance of lung cancer

[13, 25, 101, 102]

Gastric cancer

KDM5A represses its target genes CDKIs (p16, p21, and p27); it transactivates VEGF and promotes gastric tumorigenesis

Promoting proliferation metastasis, and angiogenesis

[7, 8, 103, 104]

Hepatocellular carcinoma

KDM5A is negatively regulated by miR-21, and repressed cyclin-dependent kinase inhibitors (CDKIs)

Promoting proliferation and inducing senescence

[105, 106]

Renal cell carcinoma

KDM5A induces stem-like cancer cells and promote RCC in demethylase-dependent manner

Facilitating proliferation, metastasis and inducing stemness of cancer cells

[47, 107]

Pancreatic cancer

KDM5A transcriptionally inhibits IGF2BP2 expression and MPC-1

Promoting aerobic glycolysis and cell proliferation

[108, 109]

Melanoma

KDM5A work as a tumor suppressor gene

Improving the response of melanoma to PD-L1 antibody

[110,111,112]

Ovarian cancer

KDM5A promotes cancer progression in demethylase-dependent manner

Promoting proliferation EMT, and drug resistance

[6, 113]