Skip to main content
Fig. 3 | Journal of Hematology & Oncology

Fig. 3

From: The construction, expression, and enhanced anti-tumor activity of YM101: a bispecific antibody simultaneously targeting TGF-β and PD-L1

Fig. 3

YM101 counteracted TGF-β1-induced the differentiation of Tregs, proliferation inhibition, and apoptosis of T cells. a YM101 suppressed the differentiation of Tregs caused by TGF-β1. Murine splenocytes were treated with plated-coated CD3, CD28, IL-2, TGF-β1, and YM101 or controls. The results of flow cytometry showed the ratio of Treg in CD4+ T cells. b, c YM101 reversed the TGF-β1-caused proliferation inhibition in T cells. d YM101 counteracted the TGF-β1-caused alterations in cell cycle distribution in CTLL-2. e YM101 relieved the TGF-β1-mediated apoptosis in CTLL-2. f YM101 reversed the TGF-β1-caused alterations in cell cycle distribution in HT-2. g YM101 hedged the TGF-β1-mediated apoptosis in HT-2. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 denote the significant difference relative to YM101 treatment. α-TGF-β: anti-TGF-β, α-PD-L1: anti-PD-L1

Back to article page