Fig. 4

YM101 antagonized the TGF-β1-caused changes in the cytokine release. a The heatmap showing the effects of TGF-β1 and YM101 on cytokine release during T cell activation. b–j YM101 reversed TGF-β1-mediated alterations in cytokine release including IL-2, IL-4, IL-5, IL-6, IL-9, IL-13, IL-22, TNF-α, and IL-17A. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001 denote the significant difference relative to YM101 treatment. α-TGF-β: anti-TGF-β, α-PD-L1: anti-PD-L1