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Table 1 Baseline characteristics

From: A multicenter, randomized phase III trial of hetrombopag: a novel thrombopoietin receptor agonist for the treatment of immune thrombocytopenia

Characteristics

HETROM-2.5, n = 168

HETROM-5, n = 171

Placebo, n = 85

Age, median (range), years

38 (19–70)

41 (18–74)

42 (18–71)

Age, n (%)

 18–65 years

162 (96.4)

163 (95.3)

82 (96.5)

 > 65 years

6 (3.6)

8 (4.7)

3 (3.5)

Height, median (range), cm

162.5 (147.0–182.0)

161.0 (147.0–182.0)

162.0 (150.0–185.5)

Weight, median (range), kg

61.0 (39.0–115.0)

62.5 (43.5–110.0)

63.0 (44.5–88.0)

BMI, median (range), kg/m2

23.4 (16.9–37.6)

24.4 (17.3–35.9)

23.6 (18.0–30.5)

Female, n (%)

122 (72.6)

119 (69.6)

60 (70.6)

Time since first ITP diagnosis, n (%)

 0.5–1 year

32 (19.0)

35 (20.5)

13 (15.3)

 1–3 years

53 (31.5)

56 (32.7)

19 (22.4)

 3–5 years

31 (18.5)

16 (9.4)

14 (16.5)

 ≥ 5 years

52 (31.0)

64 (37.4)

39 (45.9)

Prior splenectomy, n (%)

14 (8.3)

15 (8.8)

4 (4.7)

Bleeding (WHO bleeding scale grade 1–4), n (%)

108 (64.3)

93 (54.4)

52 (61.2)

Concomitant ITP medication at baseline, n (%)

168 (100.0)

168 (98.2)

83 (97.6)

Baseline platelet count, median (range), × 109/L

13 (1–29)

13 (2–29)

13 (1–29)

Baseline platelet count, n (%)

 < 10 × 109/L

64 (38.1)

58 (33.9)

35 (41.2)

 10–30 × 109/L

104 (61.9)

113 (66.1)

50 (58.8)

  1. HETROM-2.5, dosage was titrated from an initial dose of once-daily 2.5 mg hetrombopag; HETROM-5, dosage was titrated from an initial dose of once-daily 5 mg hetrombopag; BMI, body mass index; ITP, immune thrombocytopenia; WHO, World Health Organization