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Table 1 Summary of dysregulated circRNAs in TNBC

From: Regulatory mechanisms, functions, and clinical significance of CircRNAs in triple-negative breast cancer

CircRNAs Location Technique/cohort Method Sample type Expression in tumor Roles Biomarkers AUC Survival Functions Mechanism Gene symbol Pathway References
circGFRA1 cytoplasm MDA-MB-231/PTX qRT-PCR MDA-MB-231/PTX Up in MDA-MB-231/PTX Oncogenic Prediction of therapy response NR NR Increase the resistance of TNBC cells to PTX Sponge miR-361-5p TLR4 NR [50]
circRPPH1 cytoplasm GSE101123/20 TNBC versus 20 N qRT-PCR TNBC tissues and cells Up Oncogenic NR NR NR Proliferation and metastasis Sponge miR-556-5p YAP1 NR [60]
circSEPT9 cytoplasm RNA-seq of 4 TNBC versus 4 N/60 TNBC versus 60 N/ 80 TNBC qRT-PCR, ISH TNBC tissues and cells Up Oncogenic Diagnosis and prognosis 0.711 OS Proliferation, metastasis, apoptosis, and autophagy Sponge miR-637 LIF NR [49]
circLARP4 NR 283 BC versus 283 N 65 TNBC versus 65 N qRT-PCR TNBC tissues and cells Down Antitumor Prediction of therapy response NR NR Inhibit the resistance of TNBC cells to DOX NR NR NR [89]
circUSP42 NR RNA-seq of TNBC versus adjacent tissues/30 TNBC versus 30 N qRT-PCR TNBC tissues Down Antitumor Prognosis NR OS, DFS NR NR NR NR [98]
circABCB10 NR MDA-MB-231/PTX qRT-PCR MDA-MB-231/PTX Up in MDA-MB-231/PTX Oncogenic Prediction of therapy response NR NR Increase the resistance of TNBC cells to PTX Sponge Let-7a-5p DUSP7 NR [95]
circCDYL NR BC versus N qRT-PCR BC tissues and TNBC cells Down Antitumor NR NR NR Proliferation, migration, and invasion Sponge miR-190a-3p TP53INP1 NR [61]
circZEB1 NR 30 TNBC versus 30 N RT-qPCR TNBC tissue, cells Up Oncogenic NR NR NR Proliferation and apoptosis Sponge miR-448 eEF2k NR [58]
circGNB1 cytoplasm Microarray/222 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS, DFS Proliferation and metastasis Sponge miR-141-5p IGF1R NR [59]
hsa_circ_0131242 NR Microarray of TNBC versus normal tissues/30 TNBC versus 30 N /120 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS Proliferation and metastasis Sponge miR-2682 NR NR [79]
circEIF3M cytoplasm RNA-seq of 3 TNBC versus 3 N /20 TNBC versus 20 N RT-qPCR TNBC tissue, cells Up Oncogenic NR NR NR Proliferation, metastasis, cell cycle, and apoptosis Sponge miR-33a CCND1 NR [62]
circHER2 cytoplasm RNA-seq of 5 TNBC versus 5 N /59 TNBC versus 59 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis and prediction of therapy response NR OS Proliferation and invasion, circHER2 expressing TNBC are sensitive to Pertuzumab Encode a novel HER2 variant HER2– 103 HER2– 103 Promote EGFR/HER3 interaction and activation [75]
circPGAP3 cytoplasm 86 TNBC versus 86 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS,DFS Proliferation and metastasis Sponge miR-330-3p myc NR [64]
circUBE2D2 cytoplasm 66 TNBC versus 66 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis and prediction of therapy response NR OS Proliferation and metastasis, increase the resistance of TNBC cells to DOX Sponge miR‑512‑3p CDCA3 NR [63]
circRAD18 cytoplasm Microarray of TNBC versus adjacent tissues/31 TNBC versus 31 N/126 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Diagnosis and prognosis 0.752 OS Proliferation, metastasis, and apoptosis Sponge miR-208a/3164 IGF1 and FGF2 NR [78]
hsa_circ_0005320 cytoplasm RNA-seq of 4 TNBC versus 4 N/20 TNBC versus 20 N RTFQ-PCR TNBC tissue, cells Up Oncogenic NR NR NR proliferation, cell cycle, and apoptosis NR LIF、P-STAT3 activate LIF-STAT3 pathway [80]
hsa_circ_069718 NR Microarray of TNBC versus adjacent tissues/35 TNBC versus 35 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS Proliferation and invasion NR β-catenin, c-myc, and cyclin D1 Activate Wnt/β-catenin pathway [81]
circFBXW7 cytoplasm 473 TNBC RT-qPCR TNBC tissue, cells Down Antitumor Prognosis NR OS, DFS Proliferation and metastasis Sponge miR-197-3p and encode the FBXW7-185aa protein FBXW7 NR [74]
circCDR1as NR MDA-MB-231/5-Fu RT-qPCR MDA-MB-231/5-Fu Up Oncogenic Prediction of therapy response NR NR Increase the resistance of TNBC cells to 5-FU Sponge miR-7 NR NR [97]
circAGFG1 cytoplasm RNA-seq of 4 TNBC versus 4 N/40 TNBC versus 40 N/80 TNBC RT-qPCR, ISH TNBC tissue, cells Up Oncogenic Diagnosis and prognosis 0.767 OS Proliferation, metastasis, cell cycle, and apoptosis Sponge miR-195-5p CCNE1 NR [57]
hsa_circ_0058514 NR RNA-seq of 4 TNBC versus 4 N/20 TNBC versus 20 N RTFQ-PCR TNBC tissue, cells Up Oncogenic NR NR NR Proliferation, metastasis, cell cycle, and apoptosis NR CCNE1 and CDK2 NR [82]
circTADA2A-E6 cytoplasm Microarray of 8 specimens (4 TNBC and 4 luminal A) versus 3 normal tissues/178 BC versus 16 N /115 TNBC RT-qPCR TNBC tissue, cells Down Antitumor Diagnosis and prognosis 0.8554 OS, DFS Proliferation and metastasis Sponge miR-203a-3p SOCS3 NR [48]
circAHNAK1 cytoplasm Microarrays/20 TNBC versus 20 N/136 TNBC RT-qPCR TNBC tissue, cells Down Antitumor Diagnosis and prognosis 0.72 OS, DFS Proliferation and metastasis Sponge miR-421 RASA1 NR [56]
circITCH NR 275 BC versus 68 N/91 TNBC RT-qPCR TNBC tissue, cells Down Antitumor Prognosis NR OS Proliferation and metastasis Sponge miR-214/ miR-17 ITCH Inactivate the Wnt/β-catenin pathway [52]
circTFCP2L1 cytoplasm Microarray of 3 TNBC versus 3 N/32 TNBC versus 32 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR DFS Proliferation and migration Sponge miR-7 PAK1 NR [55]
circKIF4A cytoplasm Microarray/240 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS, DFS Proliferation and metastasis Sponge miR-375 KIF4A NR [51]
circAMOTL1 NR MDA-MB-231/PTX qRT-PCR MDA-MB-231/PTX Up in MDA-MB-231/PTX Oncogenic Prediction of therapy response NR NR Increase the resistance of TNBC cells to PTX NR BCL2, BAX and BAK AKT pathway, [96]
circKDM4C cytoplasm MDA-MB-231/DOX qRT-PCR MDA-MB-231/DOX Down MDA-MB-231/DOX Antitumor Prediction of therapy response NR NR Decreased the resistance of TNBC cells to doxorubicin Sponge miR-548p PBLD NR [90]
circPLK1 cytoplasm Microarray of four cell lines (MDA-MB-231, MDA-MB-468, BT549 versus MCF-10A)/57 TNBC versus 57 N/240 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS, DFS Proliferation and metastasis Sponge miR-296-5p PLK1 NR [54]
circANKS1B cytoplasm RNA-seq of 3 TNBC versus 3 N/20 TNBC versus 20 N/ 165 BC versus 40 N RT-qPCR BC tissue, cells Up Oncogenic Prognosis NR OS Invasion and metastasis Sponge miR-148a/ 152-3p USF1 Activate of TGF-β1 signaling pathway [47]
circUBAP2 cytoplasm 78 TNBC versus 78 N RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS Proliferation, metastasis, and apoptosis Sponge miR-661 MTA1 NR [53]
circ-ciRS-7 cytoplasm 32 TNBC versus 32 N RT-qPCR TNBC tissue, cells Up Oncogenic NR NR NR Invasion and metastasis Sponge miR-1299 MMPs NR [45]
circMTO1 nucleus MDA-MB-231/monastrol qRT-PCR MDA-MB-231/monastrol Down MDA-MB-231/ monastrol Antitumor Prediction of therapy response NR NR Reverses the resistance of TNBC cells to monastrol Binding to TRAF4 Eg5 NR [67]
circEPSTI1 NR Microarray of 3 TNBC versus 3 N/37 TNBC versus 30 N/240 TNBC RT-qPCR, ISH TNBC tissue, cells Up Oncogenic Prognosis NR OS, DFS Proliferation and apoptosis SPONGE miR-4753/6809 BCL11A NR [46]
circGFRA1 cytoplasm Microarray of TNBC cells and MCF-10A /51 TNBC versus 51 N/222 TNBC RT-qPCR TNBC tissue, cells Up Oncogenic Prognosis NR OS, DFS Proliferation and apoptosis Sponge miR-34a GFRA1 NR [29]
hsa_circ_0006528 NR MDA-MB-231/DOX qRT-PCR MDA-MB-231/DOX Up in MDA-MB-231/DOX Oncogenic Prediction of therapy response NR NR Increase the resistance of TNBC cells to PTX Sponge miR-7–5p Raf1 NR [87]
  1. TNBC triple-negative breast cancer, N normal, DOX doxorubicin, PTX paclitaxel, 5-FU 5-fluorouracil, MDA-MB-231/PTX PTX-resistant MDA-MB-231, MDA-MB-231/DOX DOX-resistant MDA-MB-231, MDA-MB-231/ monastrol monastrol-resistant MDA-MB-23, 5-Fu-resistant MDA-MB-231 MDA-MB-231/5-FU, OS overall survival, DFS disease-free survival, AUC area under the curve, NR not report, ISH in situ hybridization, qRT-PCR quantitative real-time PC