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Table 4 Summary of significant associations of circRNAs with TNBC survival

From: Regulatory mechanisms, functions, and clinical significance of CircRNAs in triple-negative breast cancer

CircRNAs Roles TNBC Patients Expression Method Sample type Cut off Univariate versus multivariate Survival HR (95%CI) Reference
circSEPT9 Oncogenic 80 Up ISH Tissue 6 Multivariate OS 3.042 (1.278–7.240), P = 0.012 [49]
circUSP42 Antitumor 30 Down RT-qPCR Tissue Median Univariate OS,DFS KM [98]
circGNB1 Oncogenic 222 Up RT-qPCR Tissue NR Multivariate OS, DFS OS, 2.148 (1.070–4.310), P = 0.031 [59]
hsa_circ_0131242 Oncogenic 120 Up RT-qPCR Tissue NR Univariate OS KM [79]
circ-HER2 Oncogenic 59 Up RT-qPCR Tissue > Adjacent Univariate OS KM [75]
circPGAP3 Oncogenic 86 Up RT-qPCR Tissue Median Univariate OS,DFS KM [64]
circUBE2D2 Oncogenic 66 Up RT-qPCR Tissue Median Univariate OS KM [63]
circRAD18 Oncogenic 126 Up RT-qPCR Tissue Median Multivariate OS 2.045 (1.010–4.143), P = 0.041 [78]
circAGFG1 Oncogenic 80 Up ISH Tissue Median Multivariate OS 6.072 (2.614–14.105), P < 0.001 [57]
circFBXW7 Antitumor 473 Down RT-qPCR Tissue Mean Multivariate OS,DFS OS, 0.215 (0.119–0.387), P = 0.001 [74]
circTADA2A-E6 Antitumor 115 Down RT-qPCR Tissue NR Univariate OS,DFS OS, 0.088 (0.011–0.714), P = 0.023; DFS, 0.094 (0.012–0.770), P = 0.028 [48]
has_circ_069718 Oncogenic 35 Up RT-qPCR Tissue NR Univariate OS KM [81]
circAHNAK1 Antitumor 136 Down RT-qPCR Tissue Median Univariate OS, DFS KM [56]
circITCH Antitumor 91 Down RT-qPCR Tissue Median Univariate OS KM [52]
circTFCP2L1 Oncogenic 32 Up RT-qPCR Tissue − 6.58 Univariate DFS KM [55]
circKIF4A Oncogenic 240 Up RT-qPCR Tissue Mean Univariate OS, DFS KM [51]
circPLK1 Oncogenic 240 Up RT-qPCR Tissue Mean Univariate OS, DFS KM [54]
circANKS1B Oncogenic 165 Up RT-qPCR Tissue Median Multivariate OS 3.29 (1.75–8.23), P = 0.008 [47]
circUBAP2 Oncogenic 78 Up RT-qPCR Tissue Median univariate OS KM [53]
circEPSTI1 Oncogenic 240 Up ISH Tissue NR univariate OS, DFS KM [46]
circGFRA1 Oncogenic 222 Up RT-qPCR Tissue Mean univariate OS, DFS KM [29]
  1. NBC triple-negative breast cancer, OS overall survival, DFS disease-free survival, NR not report, qRT-PCR quantitative real-time PCR, ISH in situ hybridization, HR hazard ratio, CI confidence interval