Regulatory mechanisms, functions, and clinical significance of CircRNAs in triple-negative breast cancer

Lyu, Lijuan; Zhang, Shizhen; Deng, Yujiao; Wang, Meng; Deng, Xinyue; Yang, Si; Wu, Ying; Dai, Zhijun

doi:10.1186/s13045-021-01052-y

Table 4 Summary of significant associations of circRNAs with TNBC survival

From: Regulatory mechanisms, functions, and clinical significance of CircRNAs in triple-negative breast cancer

CircRNAs	Roles	TNBC Patients	Expression	Method	Sample type	Cut off	Univariate versus multivariate	Survival	HR (95%CI)	Reference
circSEPT9	Oncogenic	80	Up	ISH	Tissue	6	Multivariate	OS	3.042 (1.278–7.240), P = 0.012	[49]
circUSP42	Antitumor	30	Down	RT-qPCR	Tissue	Median	Univariate	OS,DFS	KM	[98]
circGNB1	Oncogenic	222	Up	RT-qPCR	Tissue	NR	Multivariate	OS, DFS	OS, 2.148 (1.070–4.310), P = 0.031	[59]
hsa_circ_0131242	Oncogenic	120	Up	RT-qPCR	Tissue	NR	Univariate	OS	KM	[79]
circ-HER2	Oncogenic	59	Up	RT-qPCR	Tissue	> Adjacent	Univariate	OS	KM	[75]
circPGAP3	Oncogenic	86	Up	RT-qPCR	Tissue	Median	Univariate	OS,DFS	KM	[64]
circUBE2D2	Oncogenic	66	Up	RT-qPCR	Tissue	Median	Univariate	OS	KM	[63]
circRAD18	Oncogenic	126	Up	RT-qPCR	Tissue	Median	Multivariate	OS	2.045 (1.010–4.143), P = 0.041	[78]
circAGFG1	Oncogenic	80	Up	ISH	Tissue	Median	Multivariate	OS	6.072 (2.614–14.105), P < 0.001	[57]
circFBXW7	Antitumor	473	Down	RT-qPCR	Tissue	Mean	Multivariate	OS,DFS	OS, 0.215 (0.119–0.387), P = 0.001	[74]
circTADA2A-E6	Antitumor	115	Down	RT-qPCR	Tissue	NR	Univariate	OS,DFS	OS, 0.088 (0.011–0.714), P = 0.023; DFS, 0.094 (0.012–0.770), P = 0.028	[48]
has_circ_069718	Oncogenic	35	Up	RT-qPCR	Tissue	NR	Univariate	OS	KM	[81]
circAHNAK1	Antitumor	136	Down	RT-qPCR	Tissue	Median	Univariate	OS, DFS	KM	[56]
circITCH	Antitumor	91	Down	RT-qPCR	Tissue	Median	Univariate	OS	KM	[52]
circTFCP2L1	Oncogenic	32	Up	RT-qPCR	Tissue	− 6.58	Univariate	DFS	KM	[55]
circKIF4A	Oncogenic	240	Up	RT-qPCR	Tissue	Mean	Univariate	OS, DFS	KM	[51]
circPLK1	Oncogenic	240	Up	RT-qPCR	Tissue	Mean	Univariate	OS, DFS	KM	[54]
circANKS1B	Oncogenic	165	Up	RT-qPCR	Tissue	Median	Multivariate	OS	3.29 (1.75–8.23), P = 0.008	[47]
circUBAP2	Oncogenic	78	Up	RT-qPCR	Tissue	Median	univariate	OS	KM	[53]
circEPSTI1	Oncogenic	240	Up	ISH	Tissue	NR	univariate	OS, DFS	KM	[46]
circGFRA1	Oncogenic	222	Up	RT-qPCR	Tissue	Mean	univariate	OS, DFS	KM	[29]

NBC triple-negative breast cancer, OS overall survival, DFS disease-free survival, NR not report, qRT-PCR quantitative real-time PCR, ISH in situ hybridization, HR hazard ratio, CI confidence interval

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