From: Third-line therapy for chronic myeloid leukemia: current status and future directions
3L study | Efficacy |
---|---|
A retrospective study of patients receiving 2L dasatinib or nilotinib after imatinib [55] | Significant correlation between higher rates of CCyR and DMR and no treatment interruption with ≤ 2L 5-year OS was 83.0% in total and 94.5% in patients with CML-CP |
A report of patients treated with 3 sequential TKIs [27] | Best response to 3L 2GTKI in 48 patients was MMR in 5 patients, CCyR in 3 patients, partial or minor CyR in 5 patients, and CHR in 6 patients |
A report of patients treated with dasatinib or nilotinib after failing imatinib [57] | Rates of MCyR, CCyR, and MMR were 50.0%, 34.6%, and 19.2%, respectively |
A study of patients receiving 3L nilotinib or dasatinib [58] | CHR, MCyR, CyR, CCyR, and MMR rates were 31.7%, 7.3%, 14.6%, 17.1%, and 15.9%, respectively, with 14.6% having no response Overall, 14% of patients died |
A retrospective study of patients on 3L [52] | MCyR and CCyR were achieved in 15 of 45 and 11 of 52 patients, respectively Overall, 13 patients died |
A single-center study of nilotinib or dasatinib in patients who failed 2 prior TKIs [59] | CHR, CCyR, and MMR were achieved in 89%, 13%, and 24%, respectively, of patients with CML-CP Of patients with CHR, 56% lost that response within a median of 23Â months 5-year OS, PFS, and EFS were 86%, 54%, and 22%, respectively |