Fig. 11

X-ray structures of P-TEFb in complex with AFF4 and the structure of SEC disruptor. a Overview of P-TEFb-AFF4 (PDB: 4IMY). b A close-up view of the AFF4-P-TEFb(Cyclin T1) interactions. c Overview of the ternary P-TEFb-Tat-AFF4 complex (PDB: 4OR5). d A close-up view of the Tat-P-TEFb-AFF4 interface. AFF4 is shown in yellow, CDK9 in magenta, Cyclin T1 in cyan, and Tat in green. Hydrogen bonds are shown as yellow dashed lines. e Structure of SEC disruptor