Fig. 12

Solution NMR structures of AF9 in complex with AF4/DOT1L (PDB: 2LM0/2MV7) and inhibitors of the PPIs involving AF9/ENL. a, c Overview of AF9-AF4/DOT1L interaction. b, d A close-up view of AF9-AF4/DOT1L interaction. In these structures, AF9-AF4/DOT1L complexes are presented as cartoon with AF9 in cyan, AF4 in yellow, DOT1L in magenta and the linker (in AF9-AF4 complex) between them in orange. The AF9 residues involved in the interaction are shown as line model with C atoms in cyan and AF4/DOT1L residues shown as stick models with C atoms in yellow. The hydrogen bonds are shown as yellow dashed lines. e Inhibitors of the PPIs involving AF9/ENL