Fig. 13

X-ray structure of AF9/ENL YEATS in complex with inhibitors and the structure of YEATS inhibitors. a AF9 YEATS in complex with H3K9ac (PDB: 4TMP). In this structure, AF9(YEATS) is shown as cartoon with C atoms in cyan and H3K9ac as a stick model with C atoms in yellow. b The active site of AF9(YEATS)-XL-07i (PDB: 5YYF), superimposed with the structure of AF9(YEATS)-H3K9ac complex (PDB: 4TMP). c A close-up view of AF9(YEATS)-XL-07i interaction. XL-07i is shown as a stick model with C atoms in yellow. d, e The active site of ENL-SGC-iMLLT (PDB: 6HT1), superimposed with the structure of AF9(YEATS)-H3K9ac complex (PDB: 4TMP). f, g The active site of ENL-compound 1 (PDB: 6T1I) and ENL-SGC-iMLLT (PDB: 6HT1), superimposed with the structure of AF9(YEATS)-H3K9ac complex (PDB: 4TMP). SGC-iMLLT and compound 1 are shown as stick model with C atoms in green and magenta, respectively. In structures b, d and f, AF9/ENL YEATS is shown as an electrostatic surface and H3K9ac as a line model with C atoms in yellow. Hydrogen bonds are shown as dashed lines. h Structures of YEATS inhibitors