Fig. 2

X-ray structures of Menin in complex with MLL1(6–13) peptide and inhibitors. a The active site of Menin–MLL1 complex (PDB: 3U85). b A close-up view of the Menin–MLL1 interaction. c Superimposed active sites of Menin–MLL1, Menin–MI-2 (PDB: 4GQ3), Menin–MI-503 (PDB: 4X5Y), and Menin–MI-1481 (PDB: 6BXY). d A close-up view of the Menin–MI-2 interactions. e Superimposed active sites of Menin–MLL1, Menin–MIV-6R (PDB: 4OG8), Menin–M-525 (PDB: 6B41), Menin–M-808 (PDB: 6WNH), Menin–M-89 (PDB: 6E1A). f A close-up view of the Menin-MIV-6R interactions. MLL1 peptide with C atoms in yellow is shown as a tube model in (a) and (b), while a line model in (c)–(f). Compounds MI-2, MI-503, MI-1481, MIV-6R, M-525, M-808, and M-89 are shown as tube models with C atoms in green, magentas, cyan, purple, grey, blue, and orange, respectively. Menin is shown as an electrostatic surface and hydrogen bonds are shown as dashed lines