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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Fig. 5

Structure of PHD3-BRD and Cyp33-MLL1(PHD3) complex. ad X-ray structures of the PHD3-BRD protein complexes. PHD3 is shown in cyan, BRD in magenta and the flexible loop in between the two domains in orange. Overview of apo-PHD3-BRD (PDB: 3LQH) in (a). A close-up view of the PHD3-BRD interaction in b. Overview of the PHD3-BRD-H3K4-Me3 complex (PBD: 3LQJ) in c. A close-up view of the PHD3-H3K4-Me3 interaction in d. The H3K4-Me3 peptide is shown as a stick model with C atoms in yellow. Hydrogen bonds are shown as yellow dashed lines. e, f Solution NMR structure of the Cyp33-MLL1(PHD3) complex with PHD3 in cyan, Cyp33 in green and the linker between them in orange (PDB: 2KU7). Overview of Cyp33-MLL1(PHD3) complex in e, and a close-up view of Cyp33-MLL1(PHD3) interaction in f

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