Fig. 7

X-ray structures of the PPIs involving MLL1 SET and WDR5 in complex with its inhibitors. a A close-up view of the binding site of MLL1 peptide in WDR5 (PDB: 3EG6). b A close-up view of the WDR5-MLL1 interaction. c Overview of the MLL1-WDR5-RBBP5 complex (PDB: 3P4F). WDR5 is shown as cartoon in cyan and RbBP5 and MLL1 as stick models with C atoms in magentas and yellow, respectively. d A close-up view of the RbBP5-WDR5 interaction. e The active site of WDR5-MLL1 complex (PDB: 3EG6), WDR5-NαH3 (PDB: 3PSL), WDR5-Win6mer (PDB: 5SXM), WDR5-MM102 (PDB: 4GM8) and WDR5-MM589 (PDB: 5VFC). f The active site of WDR5-MM102 (PDB: 4GM8), superimposed with the structure of WDR5-MLL1 complex (PDB: 3EG6). g The active site of WDR5-MLL1 complex (PDB: 3EG6), WDR5-WDR5-0103 (PDB: 3UR4) and WDR5-C6 (PDB: 6E23). h The active site of WDR5-WDR5-0103 (PDB: 3UR4), superimposed with the structure of WDR5-MLL1 (PDB: 3EG6). i The active site of WDR5-C6 (PDB: 6E23), superimposed with the structure of WDR5-MLL1 (PDB: 3EG6). Compounds NαH3, Win6mer, MM102, MM589, WDR5-0103 and C6 are shown as stick models with C atoms in green, blue, grey, orange, purple and pink, respectively. In these structures, WDR5 is shown as an electrostatic surface and the MLL1 peptide as a line model with C atoms in yellow. Hydrogen bonds are shown as dashed lines