Fig. 9From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteinsa Illustration of AFF4, showing functional domains of P-TEFb binding domain (residues 1–73), ELL binding domain (301–350), ENL/AF9 binding domain (761–774), and the CHD domain (899–1163). b A schematic illustration showing how MLL1-AF4 oncoprotein recruits SEC as well as the biological functions of these proteins for gene regulationBack to article page