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Table 2 Inhibitors targeting PPIs involving MLL1 in clinical trials

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Drug

KO-539

SNDX 5613

Tumor type

Advanced malignant neoplasm; Acute myeloid leukemia; Mixed lineage leukemia; Mixed lineage acute leukemia; Acute leukemia of ambiguous lineage; Mixed phenotype acute leukemia

Acute myeloid leukemia; Acute lymphoblastic leukemia; Mixed lineage acute leukemia; Mixed phenotype acute leukemia; Acute leukemia of ambiguous lineage

Phase

Phase 1, Phase 2

Phase 1, Phase 2

Clinical efficacy

Not released

Not released

Safety (% patients)

Not released

Not released

Trial number

NCT04067336

NCT04065399

Status

Recruiting

Recruiting