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Table 2 Inhibitors targeting PPIs involving MLL1 in clinical trials

From: Structure, function and inhibition of critical protein–protein interactions involving mixed lineage leukemia 1 and its fusion oncoproteins

Drug KO-539 SNDX 5613
Tumor type Advanced malignant neoplasm; Acute myeloid leukemia; Mixed lineage leukemia; Mixed lineage acute leukemia; Acute leukemia of ambiguous lineage; Mixed phenotype acute leukemia Acute myeloid leukemia; Acute lymphoblastic leukemia; Mixed lineage acute leukemia; Mixed phenotype acute leukemia; Acute leukemia of ambiguous lineage
Phase Phase 1, Phase 2 Phase 1, Phase 2
Clinical efficacy Not released Not released
Safety (% patients) Not released Not released
Trial number NCT04067336 NCT04065399
Status Recruiting Recruiting