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Table 1 Roles and pathways of chemokines and their receptors in ALL

From: Targeting chemokines for acute lymphoblastic leukemia therapy

 

Pathways

Roles

References

CXCL12/CXCR4

Myc

Proliferation

[16]

Src and ABL1/RhoGDI2/RhoA and RhoC

Migration

[49, 50]

P38MAPK

Migration, homing

[40, 51]

RAC1

Migration

[52, 53]

ERK1/2

Infiltration, survival

[55]

PI3K/Akt

Survival

[60]

CCL25/CCR9

RhoA-Rock-MLC and ezrin

Infiltration

[69, 70]

PI3K/Akt-RhoA

Infiltration

[71]

P-gp/ERM/F-actin

Drug resistance

[75]

CXCL10/CXCR3

Bcl-2/caspases

Survival

[80]

MMP9

Invasion

[82]

CCR5

JAK/STAT3

Proliferation, migration

[94]