Fig. 1
From: Prostate cancer and PARP inhibitors: progress and challenges
Homologous recombination repair pathways. Double-strand breaks are detected by different proteins such as FANC complex or ATM/CHEK2. They recruit homologous stand invasion effectors, including BRCA1, BRCA2, PALB2 and RAD51, on the break site to carry out a faithful DNA repair. DSB double-strand break, HRR homologous recombination repair