Fig. 1

Mechanism of RET Gene rearrangements [12]. Models of RET rearrangements. a Schematic representation of the RET proto-oncogene (left). RET activation typically involves ligand binding, interactions with a coreceptor, and homodimerization leading to formation of a multiprotein complex (right). b Schematic representation of a KIF5B-RET fusion (left). The coiled-coil domain of KIF5B promotes ligand-independent homodimerization of RET, leading to constitutive activation of downstream growth signalling. License for reuse from John Wiley and Sons form Justin F. Gainor and Alice T. Shaw. Permission conveyed through Copyright Clearance Center, Inc. (License #: 4987820544353)