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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Oncogenetic landscape and clinical impact of IDH1 and IDH2 mutations in T-ALL

Fig. 1

IDH1 and IDH2 mutations in the GRAALL03/05 and FRALLE2000 studies. a Lollipop plots indicating the observed mutations for each IDH gene and their consequences. b Oncoplot depicting the genetic anomalies observed in IDH1/2-Mutated or Wild type T-ALL cases of the GRAALL03/05 and FRALLE2000 studies. Genes are classified by functional groups. The right panel indicates the overall frequency of alterations per gene. c The circos plots depict the co-occurrences in genetic lesions observed in IDH1 (left panel) and IDH2 mutated T-ALL (right panel). d Clinical impact of IDH1 and IDH2 mutations in the GRAALL0305 and FRALLE2000 studies. Overall survival (left panel) and cumulative incidence of relapse (right panel). The red curve represents the IDH2-mutated patients, the green curve the IDH1-mutated patients and the black curve the IDHWt patients

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