Fig. 4
From: Targeting neddylation E2s: a novel therapeutic strategy in cancer
UBE2M and UBE2F in cancer. Inhibiting the activity of UBE2M and UBE2F can inhibit cell proliferation. UBE2M can promote cell cycle progression to induce cell growth by stabilizing β-catenin and activating the neddylation of cullin1-4. UBE2M can recruit RNF111 to disturb the CtIP-BRCA1 interaction and promote H4 protein ubiquitylation via the neddylation of RNF168 to regulate DNA repair. UBE2F can reduce the level of NOXA by triggering CRL5 and then inhibit apoptosis and induce cell growth