Journal of Hematology & Oncology

Table 1 Correlation between CLK1 expression and clinicopathological characteristics of PDAC patients

From: CLK1/SRSF5 pathway induces aberrant exon skipping of METTL14 and Cyclin L2 and promotes growth and metastasis of pancreatic cancer

	Internal cohort (n = 186)					External cohort (n = 158)
		High CLK1 n = 112	Low CLK1 n = 74	χ²	p		High CLK1 n = 96	Low CLK1 n = 62	χ²	p
Age
< 60	90	50	40	1.58	0.29	94	56	38	0.14	0.42
> 60	96	62	34			64	40	24
Gender
Male	99	61	38	0.17	0.68	85	52	33	0.013	0.91
Female	87	51	36			73	44	29
BMI
≥ 28	53	33	20	0.13	0.72	62	36	26	0.31	0.58
< 28	133	79	54			96	60	36
Smoke
Yes	64	40	24	0.21	0.65	86	56	30	1.50	0.22
No	122	72	50			72	40	32
Differentiation
Low	91	49	42	3.02	0.08	77	48	29	0.16	0.69
High/middle	95	63	32			81	48	33
Lymphatic metastasis
Yes	126	85	45	4.817	0.028	88	59	26	5.776	0.016
No	60	27	29			70	37	36
Tumor size
> 4 cm	71	46	19	4.646	0.031	50	40	11	9.864	0.002
≤ 4 cm	115	66	55			108	56	51
Microvascular invasion
Yes	60	42	18	3.54	0.06	64	37	27	0.39	0.53
No	126	70	56			94	59	35
ki-67
≥ 20	74	48	26	1.11	0.29	69	43	26	0.13	0.72
< 20	112	64	48			89	53	36
TNM stage
II	116	61	55	7.49	0.006	96	53	45	4.83	0.028
III	70	51	19			62	43	17

^*P < 0.05 was considered significant

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