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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Targeting MCL-1 in cancer: current status and perspectives

Fig. 1

An overview of BCL-2 family proteins. a Schematic representation of the domains of BCL-2 family proteins. Anti-apoptotic proteins and pro-apoptotic effector proteins both contain BH domains 1–4 (BH 1–4). BH3-only proteins contain only the BH3 domain (except for BID, which has BH1-4). b The interactions of BCL-2 family proteins. Antiapoptotic proteins prevent the activation of the effector proteins BAX and BAK. BH3-only proteins are divided into “sensitizers” and “activators”. “Activators” directly activate BAX and BAK and inhibit antiapoptotic proteins. “Sensitizers” only suppress anti-apoptotic proteins. The specific interaction network is shown

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